Drug interactions
Perphenazine + Selinexor
Severity: Moderate
Perphenazine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, and other neurological adverse effects. Perphenazine is sedating and may add to these central effects, increasing the risk of falls and impaired cognition.
What this interaction means in plain words
Perphenazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion, and sedation and counsel on fall precautions. Reduce the perphenazine dose or review the need for it if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Perphenazine with Selinexor?
MediHelp rates the interaction as moderate. Perphenazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, and other neurological adverse effects. Perphenazine is sedating and may add to these central effects, increasing the risk of falls and impaired cognition.
How serious is the interaction between Perphenazine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion, and sedation and counsel on fall precautions. Reduce the perphenazine dose or review the need for it if neurological symptoms develop.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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