Drug interactions
Perphenazine + Tacrolimus
Severity: Moderate
Perphenazine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase arrhythmia risk. Tacrolimus-related electrolyte changes such as hypomagnesemia and hyperkalemia may add to this risk.
What this interaction means in plain words
Perphenazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation.
What to do
Check ECG at baseline and after changes, and keep magnesium and potassium within normal range. Consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Perphenazine with Tacrolimus?
MediHelp rates the interaction as moderate. Perphenazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase arrhythmia risk. Tacrolimus-related electrolyte changes such as hypomagnesemia and hyperkalemia may add to this risk.
How serious is the interaction between Perphenazine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and after changes, and keep magnesium and potassium within normal range. Consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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