Drug interactions
Perphenazine + Temazepam
Severity: Moderate
Perphenazine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine and temazepam are both sedating, and together they increase drowsiness, impaired coordination and the risk of falls. Respiratory depression is more likely in older or debilitated patients.
What this interaction means in plain words
Perphenazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through dopamine, histamine and GABA-A receptor effects.
What to do
Use the lowest effective doses, advise against alcohol and driving, and monitor older patients for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Perphenazine with Temazepam?
MediHelp rates the interaction as moderate. Perphenazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine and temazepam are both sedating, and together they increase drowsiness, impaired coordination and the risk of falls. Respiratory depression is more likely in older or debilitated patients.
How serious is the interaction between Perphenazine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, advise against alcohol and driving, and monitor older patients for oversedation and falls.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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