Drug interactions
Phenelzine + Propofol
Severity: Moderate
Phenelzine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may alter hemodynamic responses to anesthesia, causing unstable blood pressure and exaggerated CNS depression with propofol. The clinical significance is uncertain, but perioperative instability is the concern.
What this interaction means in plain words
Phenelzine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction between MAO inhibition-related autonomic changes and anesthetic CNS and cardiovascular depression; not fully characterized.
What to do
Inform the anesthesia team of phenelzine therapy before surgery and titrate propofol carefully. Monitor blood pressure and heart rate continuously and avoid indirect-acting sympathomimetics for rescue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Phenelzine with Propofol?
MediHelp rates the interaction as moderate. Phenelzine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may alter hemodynamic responses to anesthesia, causing unstable blood pressure and exaggerated CNS depression with propofol. The clinical significance is uncertain, but perioperative instability is the concern.
How serious is the interaction between Phenelzine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of phenelzine therapy before surgery and titrate propofol carefully. Monitor blood pressure and heart rate continuously and avoid indirect-acting sympathomimetics for rescue.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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