Drug interactions
Phenobarbital + Silodosin
Severity: Moderate
Phenobarbital and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and may lower silodosin concentrations, potentially reducing symptom relief in BPH. The effect is expected rather than well documented.
What this interaction means in plain words
Phenobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induces CYP3A4, increasing silodosin metabolism.
What to do
Monitor urinary symptom response and consider an alternative or dose reassessment if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Phenobarbital with Silodosin?
MediHelp rates the interaction as moderate. Phenobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and may lower silodosin concentrations, potentially reducing symptom relief in BPH. The effect is expected rather than well documented.
How serious is the interaction between Phenobarbital and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and consider an alternative or dose reassessment if efficacy is lost.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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