Drug interactions
Phentolamine + Sotalol
Severity: Moderate
Phentolamine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine causes vasodilation with hypotension and reflex tachycardia, and sotalol adds to the blood pressure lowering while blunting the compensation. Phentolamine can also provoke arrhythmias, which matters in a patient on a QT-prolonging drug.
What this interaction means in plain words
Phentolamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentolamine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-adrenergic blockade and beta-blockade.
What to do
Monitor blood pressure, heart rate and ECG when phentolamine is administered to patients taking sotalol. Use the lowest effective phentolamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Sotalol?
MediHelp rates the interaction as moderate. Phentolamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine causes vasodilation with hypotension and reflex tachycardia, and sotalol adds to the blood pressure lowering while blunting the compensation. Phentolamine can also provoke arrhythmias, which matters in a patient on a QT-prolonging drug.
How serious is the interaction between Phentolamine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when phentolamine is administered to patients taking sotalol. Use the lowest effective phentolamine dose.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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