Drug interactions
Phenylephrine + Silodosin
Severity: Minor
Phenylephrine and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is a highly selective alpha-1A blocker and can reduce the effects of phenylephrine. The impact on systemic blood pressure is usually modest because of its uroselectivity.
What this interaction means in plain words
Phenylephrine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phenylephrine belongs to Respiratory; Silodosin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Titrate phenylephrine to clinical response and monitor blood pressure if used for hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Phenylephrine with Silodosin?
MediHelp rates the interaction as minor. Phenylephrine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Silodosin is a highly selective alpha-1A blocker and can reduce the effects of phenylephrine. The impact on systemic blood pressure is usually modest because of its uroselectivity.
How serious is the interaction between Phenylephrine and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate phenylephrine to clinical response and monitor blood pressure if used for hypotension.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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