Drug interactions
Phenylephrine + Solriamfetol
Severity: Moderate
Phenylephrine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Adding phenylephrine can increase these effects further.
What this interaction means in plain words
Phenylephrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenylephrine belongs to Respiratory; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive pressor effects from norepinephrine reuptake inhibition and direct alpha-adrenergic agonism.
What to do
Monitor blood pressure and heart rate when phenylephrine is used with solriamfetol. Reduce or stop phenylephrine if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Phenylephrine with Solriamfetol?
MediHelp rates the interaction as moderate. Phenylephrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Adding phenylephrine can increase these effects further.
How serious is the interaction between Phenylephrine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when phenylephrine is used with solriamfetol. Reduce or stop phenylephrine if blood pressure rises.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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