Drug interactions
Pilocarpine + Sotalol
Severity: Moderate
Pilocarpine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist that can slow conduction and heart rate, especially with systemic dosing. With sotalol, bradycardia or conduction disturbances may be enhanced.
What this interaction means in plain words
Pilocarpine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Sotalol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects from muscarinic stimulation and beta-blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease. Systemic pilocarpine labeling advises caution with beta-blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Sotalol?
MediHelp rates the interaction as moderate. Pilocarpine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist that can slow conduction and heart rate, especially with systemic dosing. With sotalol, bradycardia or conduction disturbances may be enhanced.
How serious is the interaction between Pilocarpine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease. Systemic pilocarpine labeling advises caution with beta-blockers.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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