Drug interactions
Pilocarpine + Tiotropium-olodaterol
Severity: Moderate
Pilocarpine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist while tiotropium is a muscarinic antagonist, so each may partly blunt the effect of the other. The result may be reduced pilocarpine efficacy, such as less saliva production, or reduced bronchodilation, and the clinical significance is variable.
What this interaction means in plain words
Pilocarpine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for loss of effect of either drug, particularly xerostomia relief and respiratory symptoms. Adjust therapy if efficacy is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Pilocarpine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist while tiotropium is a muscarinic antagonist, so each may partly blunt the effect of the other. The result may be reduced pilocarpine efficacy, such as less saliva production, or reduced bronchodilation, and the clinical significance is variable.
How serious is the interaction between Pilocarpine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect of either drug, particularly xerostomia relief and respiratory symptoms. Adjust therapy if efficacy is reduced.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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