Drug interactions
Pilocarpine + Trazodone
Severity: Minor
Pilocarpine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist, while trazodone has weak anticholinergic activity, so it may slightly blunt pilocarpine effects. The practical impact is small.
What this interaction means in plain words
Pilocarpine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pilocarpine belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
Theoretical pharmacodynamic opposition at muscarinic receptors.
What to do
No routine change is needed; assess pilocarpine response, such as salivation, if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Trazodone?
MediHelp rates the interaction as minor. Pilocarpine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pilocarpine is a muscarinic agonist, while trazodone has weak anticholinergic activity, so it may slightly blunt pilocarpine effects. The practical impact is small.
How serious is the interaction between Pilocarpine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; assess pilocarpine response, such as salivation, if symptoms change.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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