Drug interactions
Pilocarpine + Trimipramine
Severity: Moderate
Pilocarpine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine's anticholinergic activity opposes the muscarinic agonist effect of pilocarpine, so the benefit for dry mouth may be diminished. Pilocarpine may also add to cardiac conduction effects in susceptible patients.
What this interaction means in plain words
Pilocarpine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Trimipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic receptor blockade and muscarinic agonism.
What to do
Monitor for reduced pilocarpine efficacy and adjust the dose accordingly. Consider a less anticholinergic antidepressant if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Trimipramine?
MediHelp rates the interaction as moderate. Pilocarpine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine's anticholinergic activity opposes the muscarinic agonist effect of pilocarpine, so the benefit for dry mouth may be diminished. Pilocarpine may also add to cardiac conduction effects in susceptible patients.
How serious is the interaction between Pilocarpine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pilocarpine efficacy and adjust the dose accordingly. Consider a less anticholinergic antidepressant if symptoms persist.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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