Drug interactions
Pimavanserin + Vilazodone
Severity: Moderate
Pimavanserin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin is a serotonin 5-HT2A inverse agonist, and with vilazodone it may theoretically alter serotonergic tone. Serotonin syndrome or neuroleptic malignant syndrome is possible but not well documented.
What this interaction means in plain words
Pimavanserin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Overlapping serotonergic pharmacology; the exact mechanism of any interaction is not well established.
What to do
Monitor for agitation, tremor, clonus, fever and rigidity when the combination is started or doses are changed. Stop the drugs and give supportive care if features of toxicity occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pimavanserin with Vilazodone?
MediHelp rates the interaction as moderate. Pimavanserin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin is a serotonin 5-HT2A inverse agonist, and with vilazodone it may theoretically alter serotonergic tone. Serotonin syndrome or neuroleptic malignant syndrome is possible but not well documented.
How serious is the interaction between Pimavanserin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, fever and rigidity when the combination is started or doses are changed. Stop the drugs and give supportive care if features of toxicity occur.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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