Drug interactions
Pioglitazone + Posaconazole
Severity: Minor
Pioglitazone and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is mainly metabolised by CYP2C8 with a smaller CYP3A4 contribution, so posaconazole is expected to have only a small effect. A modest rise in pioglitazone exposure could slightly increase fluid retention or hypoglycemia risk.
What this interaction means in plain words
Pioglitazone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pioglitazone belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Weak inhibition of the minor CYP3A4 pathway of pioglitazone metabolism.
What to do
No dose change is usually required; monitor glucose and signs of edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Posaconazole?
MediHelp rates the interaction as minor. Pioglitazone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is mainly metabolised by CYP2C8 with a smaller CYP3A4 contribution, so posaconazole is expected to have only a small effect. A modest rise in pioglitazone exposure could slightly increase fluid retention or hypoglycemia risk.
How serious is the interaction between Pioglitazone and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor glucose and signs of edema.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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