Drug interactions
Pioglitazone + Ubrogepant
Severity: Minor
Pioglitazone and Ubrogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is reported to be a weak CYP3A4 inducer, but any effect on ubrogepant is probably small. A minor drop in ubrogepant exposure could reduce migraine relief, although no meaningful effect is established.
What this interaction means in plain words
Pioglitazone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pioglitazone belongs to Endocrine; Ubrogepant belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction by pioglitazone could modestly increase ubrogepant metabolism.
What to do
No dose change is usually required. Evaluate the clinical response to ubrogepant and consider an alternative if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Pioglitazone with Ubrogepant?
MediHelp rates the interaction as minor. Pioglitazone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is reported to be a weak CYP3A4 inducer, but any effect on ubrogepant is probably small. A minor drop in ubrogepant exposure could reduce migraine relief, although no meaningful effect is established.
How serious is the interaction between Pioglitazone and Ubrogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Evaluate the clinical response to ubrogepant and consider an alternative if efficacy appears reduced.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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