Drug interactions
Piroxicam + Tizanidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potential additive hepatotoxicity; each has been associated with liver enzyme elevations and rare hepatic injury.
Mechanism of action
Pharmacodynamic: combined use of two agents with hepatic adverse effect potential increases overall risk of liver injury.
Clinical management
Use the lowest effective NSAID dose for the shortest duration. Check baseline and periodic LFTs during concomitant therapy; discontinue if significant elevations or symptoms of hepatitis occur.
Drug reference
References
- Piroxicam Prescribing Information – Warnings: Hepatic effects — FDA Label
- Tizanidine Prescribing Information – Warnings and Precautions: Hepatotoxicity — FDA Label
- Nonsteroidal antiinflammatory drugs (NSAIDs): Adverse effects and patient evaluation — UpToDate
Frequently asked questions
Can I take Piroxicam with Tizanidine?
The interaction is rated: Moderate. Potential additive hepatotoxicity; each has been associated with liver enzyme elevations and rare hepatic injury.
How serious is the interaction between Piroxicam and Tizanidine?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between Piroxicam and Tizanidine managed?
Use the lowest effective NSAID dose for the shortest duration. Check baseline and periodic LFTs during concomitant therapy; discontinue if significant elevations or symptoms of hepatitis occur.
Why do Piroxicam and Tizanidine interact?
Pharmacodynamic: combined use of two agents with hepatic adverse effect potential increases overall risk of liver injury.
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