Drug interactions
Piroxicam + Torsemide
Severity: Moderate
Piroxicam and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics. In volume-depleted patients the combination may also raise the risk of acute kidney injury.
What this interaction means in plain words
Piroxicam and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, blunting loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response falls. Avoid in dehydrated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Torsemide
Frequently asked questions
Can I take Piroxicam with Torsemide?
MediHelp rates the interaction as moderate. Piroxicam and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics. In volume-depleted patients the combination may also raise the risk of acute kidney injury.
How serious is the interaction between Piroxicam and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and increase the diuretic dose if response falls. Avoid in dehydrated patients.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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