Drug interactions
Pitolisant + Posaconazole
Severity: Moderate
Pitolisant and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is metabolized by CYP2D6 and CYP3A4, and strong CYP3A4 inhibition may increase its exposure. This may increase adverse effects including QT prolongation, insomnia and anxiety.
What this interaction means in plain words
Pitolisant and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of pitolisant, increasing its concentrations.
What to do
Monitor for adverse effects and QT prolongation, and consider a pitolisant dose adjustment per labeling, particularly in poor CYP2D6 metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Posaconazole?
MediHelp rates the interaction as moderate. Pitolisant and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant is metabolized by CYP2D6 and CYP3A4, and strong CYP3A4 inhibition may increase its exposure. This may increase adverse effects including QT prolongation, insomnia and anxiety.
How serious is the interaction between Pitolisant and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and QT prolongation, and consider a pitolisant dose adjustment per labeling, particularly in poor CYP2D6 metabolizers.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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