Drug interactions
Pomalidomide + Ribociclib
Severity: Moderate
Pomalidomide and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, and ribociclib may modestly raise its exposure. Both drugs can cause neutropenia, so additive myelosuppression is possible.
What this interaction means in plain words
Pomalidomide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pomalidomide belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, a partial pomalidomide clearance route, and both drugs cause myelosuppression.
What to do
Monitor complete blood counts frequently. Reduce or interrupt either drug for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Ribociclib?
MediHelp rates the interaction as moderate. Pomalidomide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, and ribociclib may modestly raise its exposure. Both drugs can cause neutropenia, so additive myelosuppression is possible.
How serious is the interaction between Pomalidomide and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently. Reduce or interrupt either drug for severe neutropenia.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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