Drug interactions
Pomalidomide + Tacrolimus
Severity: Minor
Pomalidomide and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-glycoprotein substrate, and tacrolimus inhibits this transporter. Exposure to pomalidomide may rise slightly, but the clinical significance is probably small.
What this interaction means in plain words
Pomalidomide and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus may inhibit P-glycoprotein efflux of pomalidomide.
What to do
No dose change is usually needed. Monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Tacrolimus?
MediHelp rates the interaction as minor. Pomalidomide and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-glycoprotein substrate, and tacrolimus inhibits this transporter. Exposure to pomalidomide may rise slightly, but the clinical significance is probably small.
How serious is the interaction between Pomalidomide and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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