Drug interactions
Ponatinib + Silodosin
Severity: Moderate
Ponatinib and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and may increase silodosin exposure. This could worsen orthostatic hypotension and other silodosin adverse effects.
What this interaction means in plain words
Ponatinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Silodosin belongs to Genitourinary.
Why it happens
P-glycoprotein inhibition by ponatinib reduces silodosin efflux.
What to do
Monitor for dizziness and orthostatic hypotension. Consider lowering silodosin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Silodosin?
MediHelp rates the interaction as moderate. Ponatinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and may increase silodosin exposure. This could worsen orthostatic hypotension and other silodosin adverse effects.
How serious is the interaction between Ponatinib and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and orthostatic hypotension. Consider lowering silodosin dose if adverse effects occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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