Drug interactions
Ponesimod + Propofol
Severity: Moderate
Ponesimod and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol can cause bradycardia and hypotension, and ponesimod lowers heart rate and slows AV conduction. Their combined effect may produce significant bradycardia or conduction block during anesthesia or sedation.
What this interaction means in plain words
Ponesimod and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponesimod belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive heart rate lowering via S1P modulation and propofol-related vagotonic and sympatholytic effects.
What to do
Monitor heart rate and ECG continuously during propofol administration and have atropine available. Give propofol in titrated doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Ponesimod with Propofol?
MediHelp rates the interaction as moderate. Ponesimod and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol can cause bradycardia and hypotension, and ponesimod lowers heart rate and slows AV conduction. Their combined effect may produce significant bradycardia or conduction block during anesthesia or sedation.
How serious is the interaction between Ponesimod and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG continuously during propofol administration and have atropine available. Give propofol in titrated doses.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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