Drug interactions
Posaconazole + Praziquantel
Severity: Minor
Posaconazole and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Praziquantel undergoes extensive CYP3A4 metabolism, so posaconazole may increase its concentrations. This could raise the likelihood of dose-related adverse effects such as dizziness, headache and gastrointestinal upset, though praziquantel is usually given as short courses.
What this interaction means in plain words
Posaconazole and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Praziquantel belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition reduces first-pass and systemic clearance of praziquantel.
What to do
No dose change is usually needed for short courses; monitor for increased adverse effects and advise against driving if dizzy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Posaconazole with Praziquantel?
MediHelp rates the interaction as minor. Posaconazole and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Praziquantel undergoes extensive CYP3A4 metabolism, so posaconazole may increase its concentrations. This could raise the likelihood of dose-related adverse effects such as dizziness, headache and gastrointestinal upset, though praziquantel is usually given as short courses.
How serious is the interaction between Posaconazole and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for short courses; monitor for increased adverse effects and advise against driving if dizzy.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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