Drug interactions
Posaconazole + Sorafenib
Severity: Moderate
Posaconazole and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may modestly raise sorafenib exposure, possibly increasing toxicity such as hand-foot reaction, hypertension and diarrhea. Both can affect QT.
What this interaction means in plain words
Posaconazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Sorafenib belongs to Oncology.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of sorafenib, with possible additive QT effects.
What to do
Monitor for sorafenib toxicity and ECG, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Posaconazole with Sorafenib?
MediHelp rates the interaction as moderate. Posaconazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may modestly raise sorafenib exposure, possibly increasing toxicity such as hand-foot reaction, hypertension and diarrhea. Both can affect QT.
How serious is the interaction between Posaconazole and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity and ECG, and reduce the dose if adverse effects emerge.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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