Drug interactions
Posaconazole + Sotorasib
Severity: Moderate
Posaconazole and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib may induce or modulate P-glycoprotein and CYP3A4, which could lower posaconazole levels. Reduced antifungal exposure could cause treatment failure, though the clinical data are limited.
What this interaction means in plain words
Posaconazole and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may reduce posaconazole exposure through P-gp and weak CYP3A4 induction.
What to do
Monitor for antifungal efficacy and consider posaconazole trough levels. Adjust the dose or choose an alternative antifungal if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Posaconazole with Sotorasib?
MediHelp rates the interaction as moderate. Posaconazole and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib may induce or modulate P-glycoprotein and CYP3A4, which could lower posaconazole levels. Reduced antifungal exposure could cause treatment failure, though the clinical data are limited.
How serious is the interaction between Posaconazole and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antifungal efficacy and consider posaconazole trough levels. Adjust the dose or choose an alternative antifungal if levels are low.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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