Drug interactions
Posaconazole + Sunitinib
Severity: Major
Posaconazole and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and raises sunitinib exposure, and both drugs can prolong the QT interval. The combination increases the risk of arrhythmia and sunitinib toxicity.
What this interaction means in plain words
Posaconazole and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition increasing sunitinib exposure plus additive QT prolongation.
What to do
Prefer an antifungal with less CYP3A4 inhibition. If needed, consider a sunitinib dose reduction and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Posaconazole with Sunitinib?
MediHelp rates the interaction as major. Posaconazole and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole inhibits CYP3A4 and raises sunitinib exposure, and both drugs can prolong the QT interval. The combination increases the risk of arrhythmia and sunitinib toxicity.
How serious is the interaction between Posaconazole and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal with less CYP3A4 inhibition. If needed, consider a sunitinib dose reduction and monitor ECG and electrolytes.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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