Drug interactions
Posaconazole + Telavancin
Severity: Moderate
Posaconazole and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole prolongs the QT interval and is labeled with warnings for torsades de pointes, and telavancin may add to this. The combination can increase arrhythmia risk, particularly with electrolyte disturbance.
What this interaction means in plain words
Posaconazole and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation.
What to do
Obtain baseline ECG and correct potassium, magnesium and calcium. Monitor the QTc during concurrent use and consider alternatives in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Telavancin?
MediHelp rates the interaction as moderate. Posaconazole and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole prolongs the QT interval and is labeled with warnings for torsades de pointes, and telavancin may add to this. The combination can increase arrhythmia risk, particularly with electrolyte disturbance.
How serious is the interaction between Posaconazole and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct potassium, magnesium and calcium. Monitor the QTc during concurrent use and consider alternatives in high-risk patients.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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