Drug interactions
Posaconazole + Vinorelbine
Severity: Major
Posaconazole and Vinorelbine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise vinorelbine exposure because vinorelbine is metabolised by CYP3A4. This can increase myelosuppression and neurotoxicity, including constipation or ileus.
What this interaction means in plain words
Posaconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Vinorelbine belongs to Oncology.
Why it happens
Inhibition of CYP3A4 (and possibly P-gp) reduces vinorelbine clearance.
What to do
Monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose if toxicity occurs; consider an alternative antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Posaconazole with Vinorelbine?
MediHelp rates the interaction as major. Posaconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole may raise vinorelbine exposure because vinorelbine is metabolised by CYP3A4. This can increase myelosuppression and neurotoxicity, including constipation or ileus.
How serious is the interaction between Posaconazole and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity closely and reduce the vinorelbine dose if toxicity occurs; consider an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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