Drug interactions
Posaconazole + Zuranolone
Severity: Moderate
Posaconazole and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases zuranolone exposure, which can intensify sedation, somnolence and cognitive or psychomotor impairment.
What this interaction means in plain words
Posaconazole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Zuranolone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of zuranolone.
What to do
Reduce the zuranolone dose as directed in labeling when a strong CYP3A4 inhibitor is used. Counsel patients about sedation and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Posaconazole with Zuranolone?
MediHelp rates the interaction as moderate. Posaconazole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases zuranolone exposure, which can intensify sedation, somnolence and cognitive or psychomotor impairment.
How serious is the interaction between Posaconazole and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zuranolone dose as directed in labeling when a strong CYP3A4 inhibitor is used. Counsel patients about sedation and driving.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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