Drug interactions
Potassium iodide + Propylthiouracil
Severity: Moderate
Potassium iodide and Propylthiouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodide and antithyroid drugs both lower thyroid hormone output, and they are used together deliberately before thyroid surgery or in thyroid storm. Combined use can add to hypothyroid and goitrogenic effects if prolonged.
What this interaction means in plain words
Potassium iodide and Propylthiouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Potassium iodide belongs to Endocrine; Propylthiouracil belongs to Endocrine.
Why it happens
Additive suppression of thyroid hormone synthesis and release (thionamide blocks organification, iodide causes Wolff-Chaikoff effect).
What to do
Limit combined use to short defined periods. Monitor thyroid function and watch for hypothyroidism or goiter if continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propylthiouracil
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Potassium iodide with Propylthiouracil?
MediHelp rates the interaction as moderate. Potassium iodide and Propylthiouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodide and antithyroid drugs both lower thyroid hormone output, and they are used together deliberately before thyroid surgery or in thyroid storm. Combined use can add to hypothyroid and goitrogenic effects if prolonged.
How serious is the interaction between Potassium iodide and Propylthiouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit combined use to short defined periods. Monitor thyroid function and watch for hypothyroidism or goiter if continued.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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