Drug interactions
Prasugrel + Vortioxetine
Severity: Major
Prasugrel and Vortioxetine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent antiplatelet agent and vortioxetine further impairs platelet function, increasing bleeding risk. Serotonergic antidepressants are associated with more gastrointestinal bleeding when combined with antiplatelets.
What this interaction means in plain words
Prasugrel and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prasugrel belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive platelet inhibition: P2Y12 blockade by prasugrel plus depletion of platelet serotonin by vortioxetine.
What to do
Monitor closely for bleeding and consider gastroprotection with a proton pump inhibitor. Reassess the need for the antidepressant or choose a non-serotonergic option if bleeding risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Prasugrel
Frequently asked questions
Can I take Prasugrel with Vortioxetine?
MediHelp rates the interaction as major. Prasugrel and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet agent and vortioxetine further impairs platelet function, increasing bleeding risk. Serotonergic antidepressants are associated with more gastrointestinal bleeding when combined with antiplatelets.
How serious is the interaction between Prasugrel and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and consider gastroprotection with a proton pump inhibitor. Reassess the need for the antidepressant or choose a non-serotonergic option if bleeding risk is high.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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