Drug interactions
Pravastatin + Ritonavir
Severity: Moderate
Pravastatin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-containing regimens can alter pravastatin exposure, with potential myopathy risk. Pravastatin is preferred over CYP3A4-dependent statins in this setting.
What this interaction means in plain words
Pravastatin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pravastatin belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits OATP1B1 and P-glycoprotein, affecting pravastatin disposition.
What to do
Titrate pravastatin carefully based on lipid response and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Pravastatin with Ritonavir?
MediHelp rates the interaction as moderate. Pravastatin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-containing regimens can alter pravastatin exposure, with potential myopathy risk. Pravastatin is preferred over CYP3A4-dependent statins in this setting.
How serious is the interaction between Pravastatin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pravastatin carefully based on lipid response and monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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