Drug interactions
Pravastatin + Tacrolimus
Severity: Minor
Pravastatin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may modestly reduce hepatic uptake of pravastatin, but pravastatin is commonly used in transplant recipients. Muscle toxicity is a general concern in this population.
What this interaction means in plain words
Pravastatin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible OATP1B1 inhibition by tacrolimus.
What to do
Pravastatin is a reasonable choice in transplant patients. Monitor for muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Pravastatin with Tacrolimus?
MediHelp rates the interaction as minor. Pravastatin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may modestly reduce hepatic uptake of pravastatin, but pravastatin is commonly used in transplant recipients. Muscle toxicity is a general concern in this population.
How serious is the interaction between Pravastatin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Pravastatin is a reasonable choice in transplant patients. Monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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