Drug interactions
Pravastatin + Trofinetide
Severity: Moderate
Pravastatin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and pravastatin is a substrate of these transporters. Exposure may rise, increasing the potential for myopathy.
What this interaction means in plain words
Pravastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pravastatin belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake reduces pravastatin clearance.
What to do
Monitor for muscle symptoms and consider a lower pravastatin dose. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Trofinetide
Frequently asked questions
Can I take Pravastatin with Trofinetide?
MediHelp rates the interaction as moderate. Pravastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and pravastatin is a substrate of these transporters. Exposure may rise, increasing the potential for myopathy.
How serious is the interaction between Pravastatin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider a lower pravastatin dose. Check CK if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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