Drug interactions
Praziquantel + Tucatinib
Severity: Moderate
Praziquantel and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may raise praziquantel concentrations. This can increase dose-related adverse effects such as dizziness, drowsiness and gastrointestinal upset.
What this interaction means in plain words
Praziquantel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Praziquantel belongs to Anti Parasitic; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing praziquantel metabolism.
What to do
Monitor for increased praziquantel adverse effects such as dizziness and sedation, and advise against driving. Praziquantel is usually a short course, so no dose change is typically required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Praziquantel with Tucatinib?
MediHelp rates the interaction as moderate. Praziquantel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and may raise praziquantel concentrations. This can increase dose-related adverse effects such as dizziness, drowsiness and gastrointestinal upset.
How serious is the interaction between Praziquantel and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased praziquantel adverse effects such as dizziness and sedation, and advise against driving. Praziquantel is usually a short course, so no dose change is typically required.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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