Drug interactions
Pregabalin + Ramelteon
Severity: Minor
Pregabalin and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon promotes sleep and pregabalin commonly causes drowsiness and dizziness, so combined use may increase somnolence and next-day impairment. Respiratory depression is not expected with ramelteon.
What this interaction means in plain words
Pregabalin and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pregabalin belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation and dizziness and counsel patients about driving. Lower a dose if impairment occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Ramelteon?
MediHelp rates the interaction as minor. Pregabalin and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon promotes sleep and pregabalin commonly causes drowsiness and dizziness, so combined use may increase somnolence and next-day impairment. Respiratory depression is not expected with ramelteon.
How serious is the interaction between Pregabalin and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness and counsel patients about driving. Lower a dose if impairment occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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