Drug interactions
Pregabalin + Sertraline
Severity: Minor
Pregabalin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin produces sedation and dizziness that may be additive with sertraline's CNS effects. Serious respiratory depression is chiefly a risk when opioids or other depressants are added.
What this interaction means in plain words
Pregabalin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pregabalin belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS effects; no significant pharmacokinetic interaction.
What to do
Start pregabalin low and titrate slowly, counselling about drowsiness and driving. Monitor for sedation in older patients or those on other sedatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Sertraline?
MediHelp rates the interaction as minor. Pregabalin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pregabalin produces sedation and dizziness that may be additive with sertraline's CNS effects. Serious respiratory depression is chiefly a risk when opioids or other depressants are added.
How serious is the interaction between Pregabalin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pregabalin low and titrate slowly, counselling about drowsiness and driving. Monitor for sedation in older patients or those on other sedatives.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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