Drug interactions
Pretomanid + Secobarbital
Severity: Major
Pretomanid and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid is partly metabolized by CYP3A4, and barbiturate induction may lower its levels. Subtherapeutic exposure in tuberculosis treatment risks treatment failure and resistance.
What this interaction means in plain words
Pretomanid and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pretomanid belongs to Anti Bacterial; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the clearance of pretomanid.
What to do
Avoid the combination and use a non-inducing sedative. Monitor the microbiologic and clinical response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Secobarbital?
MediHelp rates the interaction as major. Pretomanid and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid is partly metabolized by CYP3A4, and barbiturate induction may lower its levels. Subtherapeutic exposure in tuberculosis treatment risks treatment failure and resistance.
How serious is the interaction between Pretomanid and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing sedative. Monitor the microbiologic and clinical response if it cannot be avoided.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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