Drug interactions
Pretomanid + Sulindac
Severity: Major
Pretomanid and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and sulindac can rarely cause liver injury including cholestatic hepatitis. Using them together may increase the likelihood or severity of liver damage.
What this interaction means in plain words
Pretomanid and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pretomanid belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Additive hepatotoxic potential from two drugs that can independently cause liver injury.
What to do
Avoid sulindac during pretomanid therapy and use a less hepatotoxic analgesic. Monitor liver function tests regularly and stop the interacting drug if liver injury develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Sulindac?
MediHelp rates the interaction as major. Pretomanid and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and sulindac can rarely cause liver injury including cholestatic hepatitis. Using them together may increase the likelihood or severity of liver damage.
How serious is the interaction between Pretomanid and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sulindac during pretomanid therapy and use a less hepatotoxic analgesic. Monitor liver function tests regularly and stop the interacting drug if liver injury develops.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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