Drug interactions
Pretomanid + Sulphasalazine
Severity: Moderate
Pretomanid and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with liver toxicity, and sulfasalazine can also cause hepatic injury. Combined use may raise the risk of hepatotoxicity.
What this interaction means in plain words
Pretomanid and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pretomanid belongs to Anti Bacterial; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Additive hepatotoxic potential of the two drugs.
What to do
Avoid unnecessary hepatotoxic drugs during pretomanid regimens, and consider an alternative to sulfasalazine. If continued, monitor liver tests regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Sulphasalazine?
MediHelp rates the interaction as moderate. Pretomanid and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with liver toxicity, and sulfasalazine can also cause hepatic injury. Combined use may raise the risk of hepatotoxicity.
How serious is the interaction between Pretomanid and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary hepatotoxic drugs during pretomanid regimens, and consider an alternative to sulfasalazine. If continued, monitor liver tests regularly.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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