Drug interactions
Pretomanid + Verapamil
Severity: Minor
Pretomanid and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits P-glycoprotein in vitro and may increase exposure to verapamil, a P-gp substrate. Clinical impact is uncertain but may include bradycardia or hypotension.
What this interaction means in plain words
Pretomanid and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pretomanid belongs to Anti Bacterial; Verapamil belongs to Cardiovascular.
Why it happens
Pretomanid may inhibit P-gp, though the clinical effect on verapamil is not well established.
What to do
Monitor heart rate and blood pressure when pretomanid is started. Adjust the verapamil dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Verapamil?
MediHelp rates the interaction as minor. Pretomanid and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits P-glycoprotein in vitro and may increase exposure to verapamil, a P-gp substrate. Clinical impact is uncertain but may include bradycardia or hypotension.
How serious is the interaction between Pretomanid and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when pretomanid is started. Adjust the verapamil dose if adverse effects appear.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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