Drug interactions
Primaquine + Ranolazine
Severity: Moderate
Primaquine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine causes dose-related QT prolongation, and primaquine may add to it. Using both could increase the likelihood of arrhythmia, especially in patients with structural heart disease.
What this interaction means in plain words
Primaquine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation; ranolazine inhibits the delayed rectifier potassium current.
What to do
Obtain a baseline ECG and monitor the QTc after starting the combination. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Primaquine with Ranolazine?
MediHelp rates the interaction as moderate. Primaquine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine causes dose-related QT prolongation, and primaquine may add to it. Using both could increase the likelihood of arrhythmia, especially in patients with structural heart disease.
How serious is the interaction between Primaquine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc after starting the combination. Keep potassium and magnesium within normal range.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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