Drug interactions
Primaquine + Risperidone
Severity: Moderate
Primaquine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can prolong the QT interval, and primaquine may have an additive effect. This may raise the risk of torsades de pointes, particularly with other contributing factors.
What this interaction means in plain words
Primaquine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Risperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor the QTc and for symptoms such as syncope or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Primaquine with Risperidone?
MediHelp rates the interaction as moderate. Primaquine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can prolong the QT interval, and primaquine may have an additive effect. This may raise the risk of torsades de pointes, particularly with other contributing factors.
How serious is the interaction between Primaquine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct electrolyte disturbances. Monitor the QTc and for symptoms such as syncope or palpitations.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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