Drug interactions
Primaquine + Sevoflurane
Severity: Moderate
Primaquine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and primaquine may add to this effect. The risk of arrhythmia is highest perioperatively with electrolyte disturbance or other QT-active drugs.
What this interaction means in plain words
Primaquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check the preoperative QTc and correct potassium and magnesium. Monitor the ECG during anesthesia and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Primaquine with Sevoflurane?
MediHelp rates the interaction as moderate. Primaquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and primaquine may add to this effect. The risk of arrhythmia is highest perioperatively with electrolyte disturbance or other QT-active drugs.
How serious is the interaction between Primaquine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the preoperative QTc and correct potassium and magnesium. Monitor the ECG during anesthesia and avoid other QT-prolonging drugs.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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