Drug interactions
Primidone + Progesterone
Severity: Moderate
Primidone and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is metabolized partly to phenobarbital, is an enzyme inducer and can lower progesterone concentrations. Reduced efficacy of progesterone therapy, including endometrial protection or contraception, may result.
What this interaction means in plain words
Primidone and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Primidone and its metabolite phenobarbital induce CYP3A4, accelerating progesterone clearance.
What to do
Monitor for breakthrough bleeding or inadequate hormonal effect and raise the progesterone dose if clinically needed. Use additional or non-hormonal contraception when contraception is the goal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Progesterone?
MediHelp rates the interaction as moderate. Primidone and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, which is metabolized partly to phenobarbital, is an enzyme inducer and can lower progesterone concentrations. Reduced efficacy of progesterone therapy, including endometrial protection or contraception, may result.
How serious is the interaction between Primidone and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or inadequate hormonal effect and raise the progesterone dose if clinically needed. Use additional or non-hormonal contraception when contraception is the goal.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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