Drug interactions
Probenecid + Vadadustat
Severity: Moderate
Probenecid and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid increases vadadustat exposure, which may cause an excessive or too rapid rise in hemoglobin. This raises the risk of thrombotic events and other adverse reactions.
What this interaction means in plain words
Probenecid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Vadadustat belongs to Endocrine.
Why it happens
Probenecid inhibits OAT1/OAT3 transporters involved in vadadustat renal elimination, increasing its AUC.
What to do
Monitor hemoglobin closely and reduce the vadadustat dose or interrupt therapy if the rise is too rapid or excessive, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Probenecid with Vadadustat?
MediHelp rates the interaction as moderate. Probenecid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid increases vadadustat exposure, which may cause an excessive or too rapid rise in hemoglobin. This raises the risk of thrombotic events and other adverse reactions.
How serious is the interaction between Probenecid and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and reduce the vadadustat dose or interrupt therapy if the rise is too rapid or excessive, per labeling.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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