Drug interactions
Procarbazine + Risperidone
Severity: Moderate
Procarbazine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity, which may add to serotonergic effects and in theory raise the risk of serotonin syndrome with risperidone. Procarbazine also causes CNS depression, which may add to sedation from risperidone.
What this interaction means in plain words
Procarbazine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Weak MAO inhibition by procarbazine with additive serotonergic and CNS depressant effects; clinical evidence is limited.
What to do
Monitor for agitation, tremor, hyperthermia, rigidity and sedation. Stop either drug and treat if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Risperidone?
MediHelp rates the interaction as moderate. Procarbazine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibiting activity, which may add to serotonergic effects and in theory raise the risk of serotonin syndrome with risperidone. Procarbazine also causes CNS depression, which may add to sedation from risperidone.
How serious is the interaction between Procarbazine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, rigidity and sedation. Stop either drug and treat if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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