Drug interactions
Procarbazine + Rizatriptan
Severity: Contraindicated
Procarbazine and Rizatriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan is cleared mainly by MAO-A, and procarbazine has MAO-inhibiting activity. Concurrent use markedly raises rizatriptan levels and adds serotonergic effects, raising the risk of serotonin syndrome and vasoconstrictive toxicity.
What this interaction means in plain words
Procarbazine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Rizatriptan belongs to Central Nervous System.
Why it happens
MAO-A inhibition by procarbazine decreases rizatriptan metabolism and adds serotonergic activity.
What to do
Avoid rizatriptan during procarbazine treatment and for 2 weeks after stopping it. Choose a triptan not metabolized by MAO-A and monitor for serotonin toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Rizatriptan?
MediHelp rates the interaction as contraindicated. Procarbazine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rizatriptan is cleared mainly by MAO-A, and procarbazine has MAO-inhibiting activity. Concurrent use markedly raises rizatriptan levels and adds serotonergic effects, raising the risk of serotonin syndrome and vasoconstrictive toxicity.
How serious is the interaction between Procarbazine and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rizatriptan during procarbazine treatment and for 2 weeks after stopping it. Choose a triptan not metabolized by MAO-A and monitor for serotonin toxicity.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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