Drug interactions
Procarbazine + Sevoflurane
Severity: Moderate
Procarbazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitor activity and CNS depressant effects, so anesthetic requirements may be altered and hemodynamic instability may occur. The interaction is mostly predicted from the mechanism rather than well documented with sevoflurane.
What this interaction means in plain words
Procarbazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible hemodynamic lability from procarbazine's weak MAO inhibition; not firmly established for sevoflurane.
What to do
Inform the anesthesia team of procarbazine use and monitor blood pressure, heart rate and depth of anesthesia. Avoid indirect-acting sympathomimetics and treat hypotension with direct-acting agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Sevoflurane?
MediHelp rates the interaction as moderate. Procarbazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitor activity and CNS depressant effects, so anesthetic requirements may be altered and hemodynamic instability may occur. The interaction is mostly predicted from the mechanism rather than well documented with sevoflurane.
How serious is the interaction between Procarbazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of procarbazine use and monitor blood pressure, heart rate and depth of anesthesia. Avoid indirect-acting sympathomimetics and treat hypotension with direct-acting agents.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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