Drug interactions
Procarbazine + Trazodone
Severity: Contraindicated
Procarbazine and Trazodone: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibiting properties, and trazodone adds serotonergic activity, so serotonin syndrome or blood pressure swings may occur. Labeling for trazodone prohibits use with MAO inhibitors.
What this interaction means in plain words
Procarbazine and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from MAO inhibition by procarbazine and serotonin reuptake inhibition by trazodone.
What to do
Avoid the combination and allow a 14 day washout after stopping either agent before starting the other. Use a non-serotonergic option for sleep or depression during procarbazine treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Trazodone?
MediHelp rates the interaction as contraindicated. Procarbazine and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO inhibiting properties, and trazodone adds serotonergic activity, so serotonin syndrome or blood pressure swings may occur. Labeling for trazodone prohibits use with MAO inhibitors.
How serious is the interaction between Procarbazine and Trazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow a 14 day washout after stopping either agent before starting the other. Use a non-serotonergic option for sleep or depression during procarbazine treatment.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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